Welcome
to MutHuntLab

Tools and resources for genetics analysis, modeling, and research.


The process of installing application resources on the server is currently underway.

Mutation Hunter

A mutation identification tool based on BLAST algorithms.

Preparing docking files

A tool that creates a file to run docking tasks for proteins with ligands.

Analysis of microorganism genomes

Development of a neural network that allows predicting the enhancement of the effect of antibiotics in the treatment of resistant forms of pathologies.

Researcher's photo

MutHuntLab is a personal research resource, including an author's blog and data analysis tools designed for various specialists studying mutations in the genes of various microorganisms.

The project is being developed by Alexander Samchenko, an employee of the Laboratory of Structure and Dynamics of Biomolecular Systems of the Institute of Cell Biophysics of the Russian Academy of Sciences, in Pushchino (Moscow Region). The main area of ​​scientific activity is the study of molecular complexes such as DNA and proteins. In his research, the author uses methods of quantum chemistry, molecular dynamics, as well as molecular docking methods.

To automate routine tasks and speed up scientific calculations, his own scripts and programs in popular programming languages ​​— Python and C# — are actively being developed.

The laboratory has published a number of articles in peer-reviewed journals, and also created several dozen application programs and auxiliary utilities for analyzing bioinformatics data.

One of the most recently developed tools is an intuitive service with a user-friendly interface, based on popular alignment algorithms. It allows for efficient detection of mutations and comparative analysis of nucleotide or protein sequences.

The development of new solutions continues: the most successful and popular tools will be gradually integrated into the composition of the MutHuntLab platform.

The author also regularly participates in scientific conferences, where he presents his work and shares his experience with colleagues.

  • Author's scientific interests

    • Programming and automation of scientific calculations

    Structural and functional study of biomolecules

    Bioinformatics and mutation analysis

    Algorithms for searching for targets and mechanisms antibiotic resistance

  • Patents:

  • №2021665744 — Computer program for determining genetic determinants of non-plasmid antibiotic resistance. Registered on October 01, 2021
  • №2022685224 — Computer program for processing files of annotated DNA sequences. Registered on December 22, 2022

  • Publications

  • Samchenko A.A., Individual project www.muthuntlab.site 2025.
  • Kondratyev, M.S., Shcherbakov, K.A., Samchenko, A.A., Khechinashvili, N.N., Komarov, V.M. Silicon Analogs of L-Amino Acids:"Properties of Building Blocks of an Alien Biosphere Biophysics (Russian Federation), 2022, 67(2), pp. 157–164 (SCOPUS)
  • T.A. Savinova, A.A. Samchenko, Y.A. Bocharova, N.A. Mayansky, I.V. Chebotar Computer Program for Detection and Analyzing the Porin-Mediated Antibiotic Resistance of Bacteria Sovrem Tekhnologii Med. 2021; 13(6): 15–22. Published online 2021 Dec 28. doi: 10.17691/stm2021.13.6.02 (PubMed PMID: 35265355)
  • Samchenko, A.A., Komarov, V.M., Kondratyev, M.S. The Study of Steroid Keys for Androgen Receptors Biophysics (Russian Federation), 2021, 66(5), pp. 738–745 (SCOPUS)
  • Komarov V.M., Samchenko A.A. Bi-Stability of a Pyramidal Structure of NH2 Groups in Nitrous Bases and its Role in the Structural and Functional Organization of the Genomic DNA Russian Physics Journal volume 2020. Vol. 63(8), pp. 1322–1338 (SCOPUS)
  • Kondratyev M.S., Kabanov A.V., Samchenko A.A., Komarov V.M., Khechinashvili N.N. Parallel Computations in the Development of Thermostable Lipase Mutants Journal of Structural Chemistry, 2018. Vol. 59, № Issue 8. pp. 1974–1979 (SCOPUS)
  • Holyavka M.G., Artyukhov V.G., Kondratyev M.S., Samchenko A.A., Kabanov A.V., Komarov V.M., Terentyev V.V. The molecular mechanism of adsorption immobilization of inulinase on polymer matrices Biophysics, 2017. Vol. 62, № 1. pp. 5-11 (SCOPUS)
  • Samchenko, A.A., Kiselev, S.S., Kabanov, A.V., Kondratjev, M.S., Komarov, V.M. On the nature of the domination of oligomeric (dA:dT)n tracts in the structure of eukaryotic genomes Biophysics (Russian Federation), 2016, 61(6), pp. 813–824 (SCOPUS)
  • Scherbakov, K.A., Kondratiev, M.S., Samchenko, A.A., Kabanov, A.V., Komarov, V.M. The electronic structure properties of 20 L-amino acids in neutral and zwitterion forms: Quantum-chemical calculations Biophysics (Russian Federation), 2016, 61(3), pp. 361–372 (SCOPUS)
  • Holyavka M.G., Kondratyev M.S., Samchenko A.A., Kabanov A.V., Komarov V.M., Artyukhov V.G. In silico design of high-affinity ligands for the immobilization of inulinase Computers in Biology and Medicine, 2016. Vol. 71, pp. 198-204 (SCOPUS)
  • Kondratyev M.S., Lunin S.M., Kabanov A.V., Samchenko A.A., Komarov V.M., Fesenko E.E., Novoselova E.G. Structural and dynamic properties of thymopoietin mimetics. Journal of Biomolecular Structure and Dynamics, 2014. Vol. 32, № 11. pp. 1793-1801 (SCOPUS)
  • Kondratev M.S., Kabanov A.V., Komarov V.M., Khechinashvili N.N., Samchenko A.A. Experience in simulating the structural and dynamic features of small proteins using table supercomputers Biophysics. 2011. Vol. 56. № 6. pp. 1026-1032. (SCOPUS)
  • Samchenko, A.A.; Kabanov, A.V.; Komarov, V.M. On possible influence of different pathways of binding of amides with water on the "pyramidalization" of nitrogen valence bonds of peptide groups. Biophysics. 2010. (SCOPUS)